FITC标记的磷酸化抑癌基因p16抗体-抗体-抗体-生物在线
上海沪震实业有限公司
FITC标记的磷酸化抑癌基因p16抗体

FITC标记的磷酸化抑癌基因p16抗体

商家询价

产品名称： FITC标记的磷酸化抑癌基因p16抗体

英文名称： Anti-phospho-CDKN2A (Ser152)/FITC

产品编号： HZ-5254R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： IF=1:50-200

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 Rabbit Anti-phospho-CDKN2A (Ser152)/FITC Conjugated antibody

FITC标记的磷酸化抑癌基因p16抗体

 

英文名称 Anti-phospho-CDKN2A (Ser152)/FITC
中文名称 FITC标记的磷酸化抑癌基因p16抗体
别    名 p-CDKN2A/p16-INK4a(Ser152); p-p16-INK4a(Ser152); cyclin-dependent kinase inhibitor 2A;CDK4I; p16-INK4; p16-INK4a; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A, isoform 1; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cell cycle inhibitor; cyclin-dependent kinase inhibitor 2a p16Ink4a; cell cycle regulator; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 2; Cdkn2a; Arf; INK4A; MTS1; p16; p16Cdkn2a; p19ARF; CD2A1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 肿瘤  免疫学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 17kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human CDKN2A around the phosphorylation site of Ser152 [GP(p-S)DI]
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]. 

Function:
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. 

Subunit:
Heterodimer with CDK4 or CDK6. Predominant p16 complexes contained CDK6. Interacts (isoforms 1,2 and 4) with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.

DISEASE:
Note=The association between cutaneous and uveal melanomas in some families suggests that mutations in CDKN2A may account for a proportion of uveal melanomas. However, CDKN2A mutations are rarely found in uveal melanoma patients. 
Defects in CDKN2A are the cause of cutaneous malignant melanoma type 2 (CMM2) [MIM:155601]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. 
Defects in CDKN2A are the cause of familial atypical multiple mole melanoma-pancreatic carcinoma syndrome (FAMMMPC) [MIM:606719]. 
Defects in CDKN2A are a cause of Li-Fraumeni syndrome (LFS) [MIM:151623]. LFS is a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53.
Defects in CDKN2A are the cause of melanoma-astrocytoma syndrome (MASTS) [MIM:155755]. The melanoma-astrocytoma syndrome is characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma.

Similarity:
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. 
Contains 4 ANK repeats. 

Database links:
UniProtKB/Swiss-Prot: P42771.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

p16主要功能是通过抑制CDK4而阻止细胞由G1期进入S期，使细胞增殖受到限制。用于各种恶性肿瘤如肺癌、恶黑、乳腺癌的研究。目前的研究细胞周期依赖激酶抑制p16INK4a蛋白在宫颈上皮内病变(CIN)中作为一个新标记物. p16INK4a的过表达与HPV E7区(病毒早期蛋白即病毒致癌基因编码区)活性有密切相关性。 p16/CDKN2基因是新近发现的肿瘤抑制基因，已有研究表明该基因在许多肿瘤出现缺失、突变或重排现象
   

该基因产生几个转录变体，它们的第一外显子不同。已经报道了编码不同蛋白质的至少三种交替剪接变异体，其中两种编码结构相关的亚型，已知其作为CDK4激酶抑制剂。剩下的转录物包括位于该基因的其余部分上游的20 kb的交替第一外显子；该转录物包含交替的开放阅读框（ARF），其指定与其他变体的结构无关的蛋白质。该ARF产物作为抑癌蛋白p53的稳定剂起作用，因为它可以与E3泛素蛋白连接酶MDM2相互作用，并对其进行螯合，这是一种负责p53降解的蛋白质。尽管结构和功能上的差异，CDK抑制剂亚型和由该基因编码的ARF产物，通过CDK4和p53在细胞周期G1进展中的调节作用，在细胞周期G1控制中具有共同的功能。该基因在多种肿瘤中经常发生突变或缺失，被认为是一种重要的抑癌基因。[ RefSeq，SEP 2012 ]提供。