FITC标记的细胞连接相关蛋白1抗体
产品名称： FITC标记的细胞连接相关蛋白1抗体
英文名称： Anti-CLASP1/FITC
产品编号： HZ-7792R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CLASP1/FITC Conjugated antibody
FITC标记的细胞连接相关蛋白1抗体
| 英文名称 | Anti-CLASP1/FITC |
| 中文名称 | FITC标记的细胞连接相关蛋白1抗体 |
| 别 名 | CLAP1_HUMAN; clasp1; CLIP associating protein 1; CLIP associating protein CLASP1; CLIP-associating protein 1; Cytoplasmic linker associated protein 1; Cytoplasmic linker-associated protein 1; hOrbit1; MAST1; Multiple asters 1; Multiple asters homolog 1; Protein Orbit homolog 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞周期蛋白 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 169kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CLASP1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Function: Microtubule plus-end tracking protein that promotes thestabilization of dynamic microtubules. Involved in the nucleationof noncentrosomal microtubules originating from the trans-Golginetwork (TGN). Required for the polarization of the cytoplasmicmicrotubule arrays in migrating cells towards the leading edge ofthe cell. May act at the cell cortex to enhance the frequency ofrescue of depolymerizing microtubules by attaching their plus-endsto cortical platforms composed of ERC1 and PHLDB2. This corticalmicrotubule stabilizing activity is regulated at least in part byphosphatidylinositol 3-kinase signaling. Also performs a similarstabilizing function at the kinetochore which is essential for thebipolar alignment of chromosomes on the mitotic spindle. Subunit: Interacts with CLIP2, ERC1, MAPRE1, MAPRE3, microtubules,PHLDB2 and RSN. The interaction with ERC1 may be mediated byPHLDB2. Interacts with GCC2; recruits CLASP1 to Golgi membranes.Interacts with MACF1 (By similarity). Subcellular Location: Cytoplasm, cytoskeleton. Cytoplasm,cytoskeleton, centrosome. Chromosome, centromere, kinetochore.Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golginetwork (Probable). Note=Localizes to microtubule plus ends.Localizes to centrosomes, kinetochores and the mitotic spindle fromprometaphase. Subsequently localizes to the spindle midzone fromanaphase and to the midbody from telophase. In migrating cellslocalizes to the plus ends of microtubules within the cell body andto the entire microtubule lattice within the lamella. Localizes tothe cell cortex and this requires ERC1 and PHLDB2 Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the CLASP family. Contains 7 HEAT repeats. Database links: Entrez Gene: 23332 Human Entrez Gene: 76707 Mouse Entrez Gene: 304740 Rat Omim: 605852 Human SwissProt: Q7Z460 Human SwissProt: Q80TV8 Mouse Unigene: 469840 Human Unigene: 708183 Human Unigene: 138740 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
微管加末端追踪蛋白促进动态微管的稳定。涉及源自中转高尔基网络（TGN）的非中心体微管的成核。在迁移细胞朝向细胞前缘的细胞质微管阵列的极化所需的。可通过将其加端连接到由Erc1和pHLDB2组成的皮质平台上，在细胞皮层起作用，以提高解聚微管的频率。这种皮质微管稳定活性至少部分地由磷脂酰肌醇3-激酶信号调节。在着丝粒上也有类似的稳定作用，这是有丝分裂纺锤体上染色体的双极排列所必需的。