FITC标记的DNA修复蛋白Rad23抗体-抗体-抗体-生物在线
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FITC标记的DNA修复蛋白Rad23抗体

FITC标记的DNA修复蛋白Rad23抗体

商家询价

产品名称： FITC标记的DNA修复蛋白Rad23抗体

英文名称： Anti-Rad23/FITC

产品编号： HZ-7121R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-Rad23/FITC Conjugated antibody

FITC标记的DNA修复蛋白Rad23抗体

 

英文名称 Anti-Rad23/FITC
中文名称 FITC标记的DNA修复蛋白Rad23抗体
别    名 DNA repair protein RAD23; UV excision repair protein RAD23; RAD23_YEAST; YEL037C; SYGP-ORF29.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  染色质和核信号  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Saccharomyces cerevisiae, YEAST,
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Saccharomyces cerevisiae Rad23
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The RAD23 gene of Saccharomyces cerevisiae is required for excision-repair of UV damaged DNA (1). RAD23 resembles the other DNA repair genes, RAD2, RAD6, RAD7, RAD18, and RAD54, all of which also exhibit increased transcription in response to DNA damage and during meiosis (2). RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function (3). RAD23 bears a ubiquitin-like domain at its amino terminus and this ubiquitin-like domain affects protein function in a nonproteolytic manner (3). Rad23 is a highly conserved protein involved in nucleotide excision repair (NER) that associates with the proteasome via its amino-terminus (4). Its carboxy-terminal ubiquitin-associated domain is evolutionarily conserved from yeast to humans (4). In addition to a role in DNA repair events in yeast, several lines of evidence indicate that the Rad23 protein may regulate the activity of the 26 S proteasome (5).

Function:
Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes.

Subunit:
Interacts directly with PNG1.

Subcellular Location:
Nucleus. Cytoplasm.

Similarity:
Contains 2 UBA domains.
Contains 1 ubiquitin-like domain.

Database links:
UniProtKB/Swiss-Prot: P32628.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

酿酒酵母RAD23基因对紫外线损伤DNA的修复（1）是必需的。RAD23与其他DNA修复基因RAD2、RAD6、RAD7、RAD18和RAD54相似，所有这些基因在DNA损伤和减数分裂过程中也显示出增加的转录(2)。RAD23编码含有生物功能所需的类泛素结构域的核蛋白（3）。RAD23在其氨基末端具有泛素样结构域，该泛素样结构域以非蛋白水解方式影响蛋白质功能(3)。Rad23是一种高度保守的蛋白质，参与核苷酸切除修复（NER），通过氨基末端（4）与蛋白酶体结合。其羧基端泛素相关结构域从酵母到人类进化保守（4）。除了在酵母的DNA修复事件中起作用之外，几行证据表明Rad23蛋白可以调节26S蛋白酶体的活性（5）。