FITC标记的JDP2蛋白抗体
产品名称： FITC标记的JDP2蛋白抗体
英文名称： Anti-JDP2/FITC
产品编号： HZ-17200R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-JDP2/FITC Conjugated antibody
FITC标记的JDP2蛋白抗体
| 英文名称 | Anti-JDP2/FITC |
| 中文名称 | FITC标记的JDP2蛋白抗体 |
| 别 名 | Jdp2; JDP2_HUMAN; Jun dimerization protein 2; JUNDM2; Progesterone receptor co-activator. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 转运蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 19kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human JDP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: c-Jun dimerization protein (JDP) 2 binds cAMP-response element (CRE) as a homodimer or as a heterodimer with ATF-2 and c-Jun. This dimerization allows JDP2 to repress CRE-dependent transcription. JDP2 is phosphorylated by c-Jun N-terminal kinase at Thr 138. JDP2 contains a basic leucine zipper (bZIP) region for DNA-binding. The bZIP region of JDP2 interacts with the DNA binding domain (DBD) of progesterone receptor (PR) in mammalian cells. Two other coactivators, creb binding protein (CBP) and p300 CBP-associated factor (PCAF), also associate with JDP2. Thus, JDP2 appears to stimulate the N-terminal activation function domain of PR by docking to the DBD and facilitation PR interaction with other coactivators. The expression of JDP2 in PR-targeted tissues and cells supports the role for JDP2 in PR function. In addition, JDP2 may play an important role in controlling the commitment of F9 embryonal carcinoma cells to differentiation. In undifferentiated F9 cells, JDP2 recruits HDAC3 and binds the differentiation response element within the c-jun promoter. Retinoic acid-induction replaces the JDP2/HDAC3 complex with PCAF and subsequently allows the transcription of c-Jun for F9 differentiation. The gene encoding human JDP2 maps to chromosome 14q24.2. Function: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments. Similarity: Belongs to the bZIP family. ATF subfamily. Contains 1 bZIP domain. Database links: Entrez Gene: 122953 Human Entrez Gene: 81703 Mouse Entrez Gene: 116674 Rat Omim: 608657 Human SwissProt: Q8WYK2 Human SwissProt: P97875 Mouse SwissProt: Q78E65 Rat Unigene: 196482 Human Unigene: 103560 Mouse Unigene: 10721 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
c-Jun二聚化蛋白(JDP)2与cAMP应答元件(CRE)以同源二聚体或异源二聚体与ATF-2和c-Jun结合，这种二聚化使JDP2能够抑制CRE依赖的转录。JDP2在THR 138由c-Jun N-末端激酶磷酸化。JDP2包含一个用于DNA结合的碱性亮氨酸拉链（BZIP）区域。JDP2的BZIP区与哺乳动物细胞中的孕酮受体（PR）的DNA结合结构域（DBD）相互作用。另外两个共激活因子，CREB结合蛋白（CBP）和P300 CBP相关因子（PCAF），也与JDP2相关。因此，JDP2似乎通过与DBD对接并促进PR与其他辅活化剂的相互作用来刺激PR的N端激活功能域。JDP2在PR靶向组织和细胞中的表达支持JDP2在PR功能中的作用。此外，JDP2可能在控制F9胚胎癌细胞分化分化中发挥重要作用。在未分化的F9细胞中，JDP2招募HDAC3并结合c-jun启动子中的分化应答元件。维甲酸诱导用PCAF取代JDP2/HDAC3复合物，随后允许c-Jun的转录用于F9分化。编码人类JDP2的基因定位于染色体14q24.2。