FITC标记的肽聚糖识别蛋白1抗体-抗体-抗体-生物在线
上海沪震实业有限公司
FITC标记的肽聚糖识别蛋白1抗体

FITC标记的肽聚糖识别蛋白1抗体

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产品名称： FITC标记的肽聚糖识别蛋白1抗体

英文名称： Anti-PGRPS/FITC

产品编号： HZ-7673R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： IF=1:50-200

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 Rabbit Anti-PGRPS/FITC Conjugated antibody

FITC标记的肽聚糖识别蛋白1抗体

 

英文名称 Anti-PGRPS/FITC
中文名称 FITC标记的肽聚糖识别蛋白1抗体
别    名 Peptidoglycan recognition protein 1; Peptidoglycan recognition protein; PGLYRP; PGLYRP1; PGRP; PGRP S; PGRP-PEN; PGRP-S; TAG7; TNFSF 3L; TNFSF3L; PGRP1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  微生物学  神经生物学  细胞凋亡  细菌及病毒  糖蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 19kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PGRPS
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRPS, PGRPIA, and PGRP-I-beta) define a new family of human pattern recognition molecules. PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood. PGRPS is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore, may function as a neutrophil antibacterial protein. However, PGRPS may have another, as yet unidentified function because in humans it is expressed in the bone marrow 50–100 times higher than in neutrophils.

Function:
Pattern receptor that binds to murein peptidoglycans(PGN) of Gram-positive bacteria. Has bactericidal activity towardsGram-positive bacteria. May kill Gram-positive bacteria byinterfering with peptidoglycan biosynthesis. Binds also toGram-negative bacteria, and has bacteriostatic activity towardsGram-negative bacteria. Plays a role in innate immunity.

Subunit:
Homodimer; disulfide-linked. 

Subcellular Location:
Secreted. Cytoplasmic granule (Bysimilarity). 

Tissue Specificity:
Highly expressed in bone marrow. Weakexpression found in kidney, liver, small intestine, spleen, thymus,peripheral leukocyte, lung, fetal spleen and neutrophils. 

Post-translational modifications:
N-glycosylated. N-glycosylation is required for bactericidalactivity. 

Similarity:
Belongs to the N-acetylmuramoyl-L-alanine amidase 2family. 

Database links:
UniProtKB/Swiss-Prot: O75594.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

初级免疫识别是基于入侵病原体之间的共同结构。细菌表面分子，如脂多糖（LPS）和肽聚糖（PGN），已知引起免疫反应，从细胞因子释放到发烧。最近，一种被称为肽聚糖识别蛋白（PGRP）的蛋白质已经在小鼠和人中被鉴定，其与在革兰氏阳性细菌上表达的肽聚糖结合。肽聚糖（PGN）是几乎所有细菌的基本细胞壁成分，因此，它是由真核天然免疫系统识别的优良靶标。PGRP（PGRPL，PGRP，PGRPIA和PGRP-Iβ）定义了一个新的人类模式识别分子家族。PGRP-1主要在肝脏中表达。虽然肝脏不被认为是主要的免疫器官，但肝脏通过抵抗感染和通过血液清除微生物产生急性相蛋白（肝细胞）参与宿主防御。PGRP存在于中性粒细胞中，并抑制革兰氏阳性细菌的生长，因此，可作为中性粒细胞抗菌蛋白发挥作用。然而，PGRP可能还有另一种尚未鉴定的功能，因为在人类中，它在骨髓中表达比中性粒细胞高50到100倍。