EIF2S1 polyclonal antibody
产品名称： EIF2S1 polyclonal antibody
英文名称： EIF2S1 polyclonal antibody
产品编号： PAB5339
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of EIF2S1.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding S51 of human EIF2S1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Identification of a hydrogen peroxide-induced PP1-JNK1-Sp1 signaling pathway for gene regulation.
Chu S, Ferro TJ.Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L983-92. Epub 2006 Jun 30.
- 2.
- Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells.
Connolly E, Braunstein S, Formenti S, Schneider RJ.Mol Cell Biol. 2006 May;26(10):3955-65.
- 3.
- Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.
Kubota H, Obata T, Ota K, Sasaki T, Ito T.J Biol Chem. 2003 Jun 6;278(23):20457-60. Epub 2003 Apr 2.
- Entrez GeneID:
- 1965
- Gene Name:
- EIF2S1
- Gene Alias:
- EIF-2,EIF-2A,EIF-2alpha,EIF2,EIF2A
- Gene Description:
- eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
- Omim ID:
- 603907
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD, MIM 603908), and gamma (52 kD, MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM
- Other Designations:
- eIF-2-alpha,eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD )
- Related Disease