FITC标记的去泛素酶10抗体
产品名称： FITC标记的去泛素酶10抗体
英文名称： Anti-USP10/FITC
产品编号： HZ-9267R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-USP10/FITC Conjugated antibody
FITC标记的去泛素酶10抗体
| 产品编号 | bs-9267R-FITC |
| 英文名称 | Anti-USP10/FITC |
| 中文名称 | FITC标记的去泛素酶10抗体 |
| 别 名 | Deubiquitinating enzyme 10; Ubiquitin carboxyl terminal hydrolase 10; Ubiquitin carboxyl-terminal hydrolase 10; Ubiquitin specific peptidase 10; Ubiquitin specific processing protease 10; Ubiquitin specific protease 10; Ubiquitin thioesterase 10; Ubiquitin thiolesterase 10; Ubiquitin-specific-processing protease 10; UBP10_HUMAN; UBPO; USP 10; USP10. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 87kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human USP10 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]. Function: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Subunit: Interacts with G3BP, which may regulate its function. Interacts with p53/TP53, SNX3 and CFTR. Subcellular Location: Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM. Tissue Specificity: Widely expressed. Post-translational modifications: Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus. Ubiquitinated. Deubiquitinated by USP13. Similarity: Belongs to the peptidase C19 family. USP10 subfamily. Database links: Entrez Gene: 9100 Human Entrez Gene: 479625 Dog Entrez Gene: 22224 Mouse Entrez Gene: 307905 Rat Omim: 609818 Human SwissProt: Q14694 Human SwissProt: P52479 Mouse SwissProt: Q3KR59 Rat Unigene: 19403 Dog Unigene: 136778 Human Unigene: 256910 Mouse Unigene: 421337 Mouse Unigene: 24862 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
泛素是一种高度保守的蛋白质，与其他蛋白质共价连接，以调节其功能和降解。该基因编码半胱氨酸蛋白酶泛素特异性蛋白酶家族的成员。该酶特异性地从泛素结合蛋白底物中切割泛素。蛋白质存在于细胞核和细胞质中。它作为DNA结合的雄激素受体复合物的辅因子，并被Ras GTPASS途径中的蛋白质所抑制。人类基因组含有类似于该基因的几个假基因。已经发现了一些转录本，一些蛋白质编码和其他非蛋白编码，这一基因。[ RefSeq，2013年1月]提供。