FITC标记的基质金属蛋白酶-7抗体
产品名称： FITC标记的基质金属蛋白酶-7抗体
英文名称： Anti-MMP7/FITC
产品编号： HZ-0423R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-MMP7/FITC Conjugated antibody
FITC标记的基质金属蛋白酶-7抗体
| 英文名称 | Anti-MMP7/FITC |
| 中文名称 | FITC标记的基质金属蛋白酶-7抗体 |
| 别 名 | Matrilysin; Matrilysin uterine; Matrin; Matrix Metalloproteinase 7; MMP-7; MMP 7; MMP7; MPSL1; PUMP 1; Pump 1 protease; PUMP1; Uterine Matrilysin; Uterine metalloproteinase; MMP7_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 神经生物学 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MMP7 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Subcellular Location: Secreted, extracellular space, extracellular matrix (Probable). Similarity: Belongs to the peptidase M10A family. Database links: Entrez Gene: 4316 Human Entrez Gene: 17393 Mouse Entrez Gene: 25335 Rat Omim: 178990 Human SwissProt: P09237 Human SwissProt: Q10738 Mouse SwissProt: P50280 Rat Unigene: 2256 Human Unigene: 4825 Mouse Unigene: 10282 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成与降解（Synthesis and Degradation） MMP7属于MMP基因家族的成员之一，MMP-7又称溶基质蛋白素(Matrilysin)，其主要功能为降解粘蛋白、纤维连结蛋白和层粘连蛋白，在肿瘤细胞突破基底膜屏障和浸润、转移中起重要作用。目前主要用于各种恶性肿瘤(如乳腺癌、胃肠道癌、卵巢癌、膀胱癌等)转移、浸润的研究及用于机体各种组织的发育和修复、肿瘤发生发展、炎症反应等过程中作用的研究 |
蛋白的基质金属蛋白酶（MMP）家族的成员都参与了细胞外基质的击穿在正常生理过程，如生殖、发育和组织的发展，remodeling，以及在疾病过程，如类风湿关节炎和肿瘤转移。分泌的基质金属蛋白酶9的是灭活的，当被激活cleaved-caspase-3 proproteins是细胞外蛋白酶。由这种基因编码的酶degrades proteoglycans纤粘蛋白，蛋白和酪蛋白，和基质金属蛋白酶家族成员不同，从最lacks conserved在它在C -末端蛋白域。的酶是参与创伤愈合的研究，和它的suggest刺激小鼠肠粘膜中的防御素的活性。该基因簇的一部分，基质金属蛋白酶基因定位到染色体11q22.3.[提供] RefSeq，2008年7月