FITC标记的G蛋白偶联受体1抗体
产品名称： FITC标记的G蛋白偶联受体1抗体
英文名称： Anti-GPR1/FITC
产品编号： HZ-12019R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GPR1/FITC Conjugated antibody
FITC标记的G蛋白偶联受体1抗体
| 英文名称 | Anti-GPR1/FITC |
| 中文名称 | FITC标记的G蛋白偶联受体1抗体 |
| 别 名 | G protein coupled receptor 1; G-protein coupled receptor 1; GPR1; GPCR1/GPR1; GPR1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPR1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. Gpr1 is required for yeast-to-hypha transition on various solid hypha-inducing media, and important for yeast cell morphology. It activates guanine nucleotide exchange on Gpa2 which stimulates cAMP synthesis by glucose. In Saccharomyces cerevisiae, Gpr1 is necessary for filamentous and invasive growth. Function: Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in hippocampus. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 2825 Human Entrez Gene: 25457 Rat Omim: 600239 Human SwissProt: P46091 Human SwissProt: P46090 Rat Unigene: 184907 Human Unigene: 81208 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
G蛋白偶联受体(GPR)是跨膜受体的蛋白家族，将细胞外信号(配体结合)传递到细胞内信号(G蛋白激活)。GPR信号是所有真核生物用来感知环境刺激并介导细胞-细胞通讯的进化古老机制。所有的受体都有七个跨膜结构域，受体的胞外部分可以糖基化。这些细胞外环还含有两个高度保守的半胱氨酸残基，它们产生二硫键以稳定受体结构。GPR1是酵母在各种固体菌丝诱导培养基上进行菌丝转变所必需的，对酵母细胞形态具有重要意义。它激活GPA2鸟嘌呤核苷酸交换，刺激葡萄糖合成cAMP。在酿酒酵母中，GPR1对于丝状和侵入性生长是必需的。