FITC标记的次黄嘌呤磷酸核糖基转移酶1抗体
产品名称： FITC标记的次黄嘌呤磷酸核糖基转移酶1抗体
英文名称： Anti-HPRT/FITC
产品编号： HZ-9026R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-HPRT/FITC Conjugated antibody
FITC标记的次黄嘌呤磷酸核糖基转移酶1抗体
| 产品编号 | bs-9026R-FITC |
| 英文名称 | Anti-HPRT/FITC |
| 中文名称 | FITC标记的次黄嘌呤磷酸核糖基转移酶1抗体 |
| 别 名 | HGPRT; HGPRTase; HPRT 1; HPRT_HUMAN; HPRT1; Hypoxanthine guanine phosphoribosyltransferase; Hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome); Hypoxanthine phosphoribosyltransferase 1; Hypoxanthine-guanine phosphoribosyltransferase; HPRT_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HPRT |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009]. Function: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. Subunit: Homotetramer. Subcellular Location: Cytoplasm. DISEASE: Defects in HPRT1 are the cause of Lesch-Nyhan syndrome (LNS) [MIM:300322]. LNS is characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation. Defects in HPRT1 are the cause of gout HPRT-related (GOUT-HPRT) [MIM:300323]; also known as HPRT-related gout or Kelley-Seegmiller syndrome. Gout is characterized by partial enzyme activity and hyperuricemia. Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Database links: Entrez Gene: 395653 Chicken Entrez Gene: 3251 Human Entrez Gene: 15452 Mouse Entrez Gene: 24465 Rat Omim: 308000 Human SwissProt: Q9W719 Chicken SwissProt: P00494 Chinese Hamster SwissProt: P00492 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白质是转移酶，通过5-磷酸核糖基焦磷酸转移5-磷酸核糖基，催化次黄嘌呤转化为肌苷酸和鸟嘌呤到鸟苷酸一磷酸。这种酶在嘌呤核苷酸产生的嘌呤补救途径中发挥核心作用。该基因的突变导致LaskyNhann综合征或痛风。[由RefSeq，Jun 2009提供。